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What Is Buprenorphine?

Buprenorphine is a synthetic and partial opioid agonist that is known by its generic name, Subutex. It is an essential element used in the comprehensive treatment plan of OUD with counseling, social, and behavioral therapies.

This medication is available under common brand names Belbuca, Brixodi, Buprenex, Butrans, Buvidal, Sixmo, Sublocade, Subovone, and Zubsolv.

It is a partial opioid agonist used to treat Opioid Use Disorder (OUD) and moderate to severe pain. This medication also helps in reducing Opioid cravings and withdrawal symptoms.

It is used in medication assessment treatment (MAT) to help people quit their addiction to Opioid medications such as pain relievers like morphine.

It also reduces depression symptoms and decreases the risk of suicidal thoughts. When taken at analgesic doses, Buprenorphine is 20 – 50 times more potent than Morphine.

These tablets are white in color and round in shape, with two imprints on the side indicating that they are of 2 mg strength. It is available in various strengths, such as (Buprenorphine 2mg, 4mg, 8mg, and 12 mg).

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How Does It Work?

Buprenorphine works by binding to several opioid receptors of the brain and attaches more strongly than any other opioid medication.

It helps to reduce feelings of pain by interrupting the way nerves signal the pain between the brain and the body.

It eliminates the effects of other opioid medications, reduces the negative effects of withdrawals, and prevents the harm associated with opioid use.

Buprenorphine starts working within one to two hours after use and has a more rapid onset of action than methadone.

Who Should Use Buprenorphine?

People with Opioid Use Disorder (OUD) and those who are suffering from moderate to severe pain can use Buprenorphine on prescription to ensure safety.

Opioid Use Disorder (OUD) –

• Buprenorphine is mainly used to treat opioid dependence and addiction by reducing opioid cravings and withdrawal symptoms.
• Being a synthetic opioid agonist, it is an essential part of the treatment plan for Opioid Use Disorder (OUD) that is combined with social and behavioral training and individual counseling to help with OUD and to provide a whole-person approach.

Buprenorphine treatment helps in –

• Lowering the risk of opioid abuse
• Diminishing Opioid dependency and addiction
• Reducing opioid cravings and withdrawals
• Increasing safety in case of overdose

Moderate To Severe Pain –

• This medication is also used to treat and manage both moderate to severe pain and provide instant relaxation caused by opioid withdrawals.

It offers various benefits to people with Opioid addiction and to those whose treatment with alternative medications like Methadone is not sufficient and is less convenient.

Buprenorphine Doses

The dose depends on various factors such as age, health, and in-depth assessment by a doctor. It is prescribed for short-term pain due to its potential for abuse, misuse, and addiction.

Sublingual Tablets –

• The recommended dose to be used after treatment, induction, and stabilization is 4 – 24 mg taken sublingually in a day.
• The target dose of this medication is 16mg, which is taken in a day.
• Do not exceed Buprenorphine doses to more than 24mg strength in a day.

Who Should Not Take Buprenorphine?

Buprenorphine can be used by most adults diagnosed with Opioid Use Disorder (OUD), but people with certain health conditions are not advised to use this medication.

Do not use Buprenorphine if you have –

• Hypersensitivity
• Seizures or fits
• Low-blood pressure
• Severe liver disease
• Urination problems
• Breathing problems
• Severe heart disease
• History of alcohol abuse
• Stomach or bowel blockage
• Used any narcotic drug in the past 14 days

Possible Buprenorphine Side Effects

Buprenorphine causes common/mild side effects that does not causes any serious harm to your health, and can be easily treated or treated.

Some of the most notable side effects of Buprenorphine are –

• Fever or high temperature
• Confusion or irritability
• Headache
• Opioid cravings
• Nausea or sickness
• Vomiting
• Constipation
• Muscle pain or cramps
• Feeling sleepy and tired
• Rashes on the skin

Being an opioid medication, Buprenorphine causes euphoric effects just like any other opioid medication and has the potential to cause respiratory depression, but it is relatively less harmful than Methadone treatment.

Expert Tips You Should Know Before Using Buprenorphine

You must take these preventative measures while using Buprenorphine for safe and effective OUD treatment.

• Do not combine or mix it with other CNS depressants such as alcohol or Benzodiazepine medications.
• Monitor for any side effects if you are suffering from any liver-related issues, and stop using the medication if you experience any symptoms.
• Avoid drinking alcohol or using any illicit drugs, sedatives, or tranquilizers that can slow your breathing, leading to overdose.
• Pregnant women are not recommended to use it without consulting their doctor to prevent any harmful effects on the baby.
• Breastfeeding mothers should avoid using this medication, as the formula can pass through milk, which can be harmful to the neonates.
• Immediately stop using the medication if you experience any unusual allergic reaction to it.

Final Words

If this medication is not used as prescribed by a doctor, it can be harmful, as it carries a risk of abuse, misuse, and dependence, but the risks are lower than those of Methadone.

Do not use Buprenorphine for a longer period of time; otherwise, you may develop dependency and get addicted to it. People who are not diagnosed with Opioid use Disorder (OUD) should not use this medication.

Avoid sharing this medication with older adults, and keep it out of reach of children. If your treatment has been completed, you must return the tablets to a pharmacy or a medical store to prevent any abuse, misuse, and dependence.

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